Immune cell infiltration – Communicable Diseases Research

Induction of pulmonary HLA-G expression by SARS-CoV-2 infection

Article

Published on 2022-11-052022-11-15
Journal: Cellular and Molecular Life Sciences
[Category] SARS, 치료기술, 치료제,

Humanized mice for investigating SARS-CoV-2 lung infection and associated human immune responses

Article

Published on 2022-10-012022-11-15
Journal: European Journal of Immunology
[Category] COVID19(2023년), SARS, 치료기술,

IFI44 is an immune evasion biomarker for SARS-CoV-2 and Staphylococcus aureus infection in patients with RA

Article

Published on 2022-09-152022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 바이오마커, 유전자 메커니즘,

[키워드] 1,25-dihydroxy vitamin D3 activated acute respiratory syndrome analyses Analysis applied autoimmune conditions Bacteremia Bacterial Bacterial infection Bacterial infections Bioinformatics analysis Biomarker caused Cell cell membrane CIBERSORT conducted coronavirus COVID-19 Cytoscape database dataset datasets DEGs dendritic cell dendritic cells dendritic cells. differentially expressed differentially expressed gene disease DNA drug target Effectiveness examined expression FIVE functional enrichment Functional enrichment analysis GBP1 gene network GeneMANIA Genes global pandemic HERC5 humans identify Ifi44 IFI44L IFIT3 IFIT5 IFN signaling IFN signaling pathway IFN-α/β Immune cell infiltration immune cells Immune escape immune evasion immune system Immunological response Infection infections infiltration Intersection ISG15 KEGG mechanism miRNA molecular mechanism molecular target NLR OAS1 oxidative phosphorylation pathogenic bacteria pathway Patient platform positive correlation PPI network prevalent proliferation promote regulate Regulation Rheumatoid rheumatoid arthritis risk factor ROC curves RSAD2 Rtp4 SARS-CoV-2 SARS-COV-2 infection severe coronavirus disease signaling pathway Staphylococcus Staphylococcus aureus target the SARS-CoV-2 therapeutic viral infection viral replication virus were used YY1
[DOI] 10.3389/fimmu.2022.1013322 PMC 바로가기

The regulation of ISG20 expression on SARS-CoV-2 infection in cancer patients and healthy individuals

Article

Published on 2022-09-132022-11-15
Journal: Frontiers in Immunology
[Category] SARS, 변종, 치료제,

[키워드] analyzed anti-SARS-CoV-2 anticancer Bone marrow Cancer cancer cell cancer cell lines cancer patient Cancer patients chemokine combating cordycepin cordycepin (CD). correlated COVID-19 COVID-19 pandemic domain exhibited expression functional healthy healthy individual highest immune Immune cell infiltration immune infiltration individuals information inhibit Invasion ISG20 ISG20 expression isoform less Lymphocytes lymphoid tissues marker Methylation MHC molecule mRNA expression mutant N6 N6-dimethyladenosine (m 6 2A) outcome overexpression promoter receptors Regulation SARS-CoV-2 SARS-COV-2 infection significantly significantly increased significantly lower small molecule survival survival rate susceptibility the median therapeutic potential tissue tissues traditional Chinese medicines treat tumorigenesis underlie virus were used
[DOI] 10.3389/fimmu.2022.958898 PMC 바로가기

Bioinformatics analysis of potential pathogenesis and risk genes of immunoinflammation-promoted renal injury in severe COVID-19

Article

Published on 2022-08-162022-11-15
Journal: Frontiers in Immunology
[Category] 바이오마커,

[키워드] activated addition Algorithm ALOX5 Analysis bioinformatics caused CD38 Cell characterized clinical utility correlated COVID-19 COVID-19 patient COVID-19 patients cytokine cytokine receptor dataset dendritic cells enrichment analysis expression expression pattern gene co-expression network Genes glomerular filtration rate HCK identify immune Immune cell Immune cell infiltration Including independent data set indicated Inflammation Inflammatory Injury Interaction involved ischemia-reperfusion injury ITGAX KEGG LYN macrophages MAPK3 Mild Miner moderate NCF4 necroptosis network analysis Neutrophils nomogram Pathogenesis pathway Pathways performed Peripheral blood poor prognosis PPI progression promoted protein-protein interaction random renal renal injury. risk screened SELP Sequencing analysis severe COVID-19 SPI1 STEM TLR2 TLR4 toll-like receptor signaling transcriptomic Viral protein WGCNA
[DOI] 10.3389/fimmu.2022.950076 PMC 바로가기

Dnah9 mutant mice and organoid models recapitulate the clinical features of patients with PCD and provide an excellent platform for drug screening

Research

Published on 2022-06-212022-10-05
Journal: Cell Death & Disease
[Category] 변종,

C1R, CCL2, and TNFRSF1A Genes in Coronavirus Disease-COVID-19 Pathway Serve as Novel Molecular Biomarkers of GBM Prognosis and Immune Infiltration

코로나바이러스 질병-COVID-19 경로의 C1R, CCL2 및 TNFRSF1A 유전자는 GBM 예후 및 면역 침투의 새로운 분자 바이오마커 역할을 합니다

Article

Published on 2022-06-182022-09-11
Journal: Disease Markers
[Category] MERS, 바이오마커, 진단,

[키워드] Analysis analysis Bioinformatics analysis Biomarker Brain Brain tumor CCL2 Cell coronavirus coronavirus disease correlation database DEGs differentially expressed gene Early detection experiment expression expression level expression levels glioblastoma multiforme identify Immune cell Immune cell infiltration immune cells immune infiltration immune response indicated infiltration involved KEGG molecular mRNA expression novel pathway Pathways Patient patients prevalent Prognosis proportion protein-protein interaction significant difference significantly survival tissue TNFRSF1A Treatment Tumor used data
[DOI] 10.1155/2022/8602068 PMC 바로가기 [Article Type] Article

Melatonin drugs inhibit SARS-CoV-2 entry into the brain and virus-induced damage of cerebral small vessels

Article

Published on 2022-06-132022-10-04
Journal: Cellular and Molecular Life Sciences
[Category] COVID19(2023년), SARS, 신약개발,

[키워드] ACE2 acute phase analysis binding Brain Brain infection Cell clinical symptom clinically complex COVID-19 disease drug Drug repurposing drugs Endothelial cell entry receptor Human human Angiotensin-converting enzyme Immune cell infiltration IMPROVE Infection infection with SARS-CoV-2 Inflammation Inflammatory inhibit SARS-CoV-2 involved K18-hACE2 K18-hACE2 mice long-lasting melatonin Neuro-vasculature Neurological symptom Neurological symptoms Perspective Prevent prevented prevention reducing SARS-CoV-2 SARS-CoV-2 entry SARS-CoV-2. small vessel survival symptoms of COVID-19 the disease therapeutic Treatment triggered vessels
[DOI] 10.1007/s00018-022-04390-3 PMC 바로가기 [Article Type] Article

Expressions and significances of CTSL, the target of COVID-19 on GBM

CTSL의 표현 및 중요성, GBM에서 Covid-19의 목표

Article

Published on 2022-03-012022-08-31
Journal: Journal of cancer research and clinical oncology
[Category] MERS, SARS, 바이오마커,

New Approach for Targeted Treatment of Mild COVID-19 by Honeysuckle through Network Pharmacology Analysis

네트워크 약리학 분석을 통한 인동덩굴의 경증 COVID-19 표적 치료를 위한 새로운 접근 방식

Research Article

Published on 2022-02-212022-09-11
Journal: Computational and Mathematical Methods in Medicine
[Category] COVID19(2023년), MERS, SARS, 신약개발, 유전자 메커니즘, 진단, 치료제,

[키워드] Analysis Cell Chinese CIBERSORT collected complex component coronavirus disease Coronavirus disease 2019 correlated Correlation analysis COVID-19 Data quality database differentially expressed differentially expressed gene effective enrichment analysis evaluated expression expressions FIVE Gene Expression Omnibus Genes GEO hematopoietic stem cells honeysuckle Immune cell infiltration immune cells immune signaling pathways Infection infiltration ingredient MAP3K7 mechanism Medicine Mild molecular natural killer network New NK cell NK cells objective overlapping Patient pharmacokinetics pharmacological Pharmacology positive correlation predict proportion protective effect RELA Result Safe screened Seven significantly statistically significant suggested target targets TCMSP toolkit Traditional Traditional Chinese medicine Transcriptome was related
[DOI] 10.1155/2022/9604456 PMC 바로가기 [Article Type] Research Article